Process for preparing pure L- alpha -glycerylphosphoryl-D-myoinositol and its salts

Process for preparing pure L- alpha -glycerylphosphoryl-D-myoinositol and its salts

PCT No. PCT/EP91/00216 Sec. 371 Date Aug. 5, 1992 Sec. 102(e) Date Aug. 5, 1992 PCT Filed Feb. 5, 1991 PCT Pub. No. WO91/12256 PCT Pub. Date Aug. 22, 1991.A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L-(alpha...

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Hauptverfasser: TRONCONI, GIOVANNI
Format: Patent
Sprache:eng
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PCT No. PCT/EP91/00216 Sec. 371 Date Aug. 5, 1992 Sec. 102(e) Date Aug. 5, 1992 PCT Filed Feb. 5, 1991 PCT Pub. No. WO91/12256 PCT Pub. Date Aug. 22, 1991.A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L-(alpha)-Glycerylphosphoryl-D-Myoinositol, passing an aqueous solution of the salt through an acid resin in H form whereby ion exchange occurs and the acid L-(alpha)-Glycerylphosphoryl-D-Myoinositol is eluted by washing the resin with water. Then the aqueous solution is passed through a basic resin whereby the L-(alpha)-Glycerylphosphoryl-D-Myoinositol is adsorbed on the resin as the anion. The resin is eluted first with a dilute solution of formic, acetic or propionic acid and then eluted with a more concentrated solution of the same acid. The preparation of severals salts is also described.