Biologically active factor

The invention comprises a factor having the following characteristics: a) It inhibits granulocyte-macrophage colony and cluster formation; b) It has a molecular weight of about 8 kDa as determined by SDS-PAGE; c) It has a weak anionic charge at pH 7.4 as shown by anion exchange chromatography; d) It...

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Bibliographische Detailangaben
Hauptverfasser:	GENTILE, PATRICK S, BROXMEYER, HAL E, MANTEL, CHARLIE R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention comprises a factor having the following characteristics: a) It inhibits granulocyte-macrophage colony and cluster formation; b) It has a molecular weight of about 8 kDa as determined by SDS-PAGE; c) It has a weak anionic charge at pH 7.4 as shown by anion exchange chromatography; d) It has a flattened isoelectric titration curve as shown by anion exchange chromatography; and d) It is a protein. The invention also comprises methods of making and using the factor and compositions comprising the factor.