17-spirofuran-3'-ylidene steroids

17-spirofuran-3'-ylidene steroids

The invention relates to an antiprogestin 17- spirofuran-3'-ylidene steroid having the formula (* CHEMICAL STRUCTURE *) I p0 R1 is NR2R3, lower acyl, OH, SH, O-lower alkyl or S(O)n-lower alkyl wherein n is 0-2; R2 and R3 are independently selected from hydrogen and lower alkyl; R4 is hydrogen o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ORLEMANS, EVERARDUS O. M, HAMERSMA, JOHANNES A. M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Beschreibung
Zusammenfassung:The invention relates to an antiprogestin 17- spirofuran-3'-ylidene steroid having the formula (* CHEMICAL STRUCTURE *) I p0 R1 is NR2R3, lower acyl, OH, SH, O-lower alkyl or S(O)n-lower alkyl wherein n is 0-2; R2 and R3 are independently selected from hydrogen and lower alkyl; R4 is hydrogen or lower alkyl; R5 is O, (H,H), (H,OH), (H,O-lower acyl), or NOH; R6 and R7 are both hydrogen, or one is hydrogen and the other lower alkyl; and the twitched line represents an (alpha) or (beta) bond.