Penta and tetrasubstituted piperidines and compositions and method of treating psychosis

Penta and tetrasubstituted piperidines and compositions and method of treating psychosis

The invention is related to compounds, being useful in treating psychosis, of the formula: wherein: R1 is hydrogen, lower-alkyl or phenyl-lower-alkyl; R2 and R4 are the same or different lower-alkyl; R3 is hydrogen or lower-alkyl; m is two or three; n is an integer from zero to three; and R5 is hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MALLAMO, JOHN P, DEHAVEN-HUDKINS, DIANE L, HEIMANN, MARTHA R, MICHNE, WILLIAM F
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention is related to compounds, being useful in treating psychosis, of the formula: wherein: R1 is hydrogen, lower-alkyl or phenyl-lower-alkyl; R2 and R4 are the same or different lower-alkyl; R3 is hydrogen or lower-alkyl; m is two or three; n is an integer from zero to three; and R5 is hydrogen, lower-alkyl, C3-C7-monocyclic cycloalkyl, allyl, or propargyl; or a pharmaceutically acceptable acid-addition salt thereof. The invention is related to compounds, being useful in treating psychosis, of the formula: (* CHEMICAL STRUCTURE *) wherein: R1 is hydrogen, lower-alkyl or phenyl-lower-alkyl; R2 and R4 are the same or different lower-alkyl; R3 is hydrogen or lower-alkyl; m is two or three; n is an integer from zero to three; and R5 is hydrogen, lower-alkyl, C3-C7-monocyclic cycloalkyl, allyl, or propargyl; or a pharmaceutically acceptable acid-addition salt thereof.