Solid dispersion compositions of tebufelone

The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components: (a) from about 15% to about 75% of tebufelone; (b) from about 25% to about 65% of a poloxamer surfactant having a melting...

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Bibliographische Detailangaben
Hauptverfasser: DOBROZSI, DOUGLAS J, KELM, GARY R
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The subject invention relates to compositions in dosage form comprising a solid dispersion which is a solidified melt mixture consisting essentially of the following components: (a) from about 15% to about 75% of tebufelone; (b) from about 25% to about 65% of a poloxamer surfactant having a melting point of about 40 degrees C. or greater, the poloxamer surfactant consisting essentially of a block copolymer having three polymer blocks, a middle block of poly(oxypropylene) with a molecular weight of from about 1450 daltons to about 6000 daltons, and end blocks of poly(oxyethylene), the end blocks being from about 50% to about 90% of the copolymer; and (c) from 0% to about 60% of other components, wherein the other components are miscible with a melt mixture of components (a) and (b).