Polystyrene anion exchange polymers

Polymers of structure : in which X is CH2, CO or CHOH; Z is H or a group X(CH2)nN/R R R ; n is 1 to 20; R and R are the same or different and are each C1-4alkyl; R is C1-20alkyl; or R , R and R together with the nitrogen atom to which they are attached form a ring, optionally containing one or more...

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Hauptverfasser: HICKEY, DEIRDRE M. B, SHAH, VIRENDRA P, JAXAAMIEC, ALBERT A
Format: Patent
Sprache:eng
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Zusammenfassung:Polymers of structure : in which X is CH2, CO or CHOH; Z is H or a group X(CH2)nN/R R R ; n is 1 to 20; R and R are the same or different and are each C1-4alkyl; R is C1-20alkyl; or R , R and R together with the nitrogen atom to which they are attached form a ring, optionally containing one or more further heteroatoms, and optionally being substituted with a C1-4alkyl group; a, b and c are numbers which indicate the relative molar percentages of the units present in a random distribution in said polymer, (b) being from about 0.5 to about 10 molar percent, and (c) being from about 30 to about 99 molar percent; m is a number indicating the degree of polymerization of said polymer, and Y is a physiologically acceptable counter ion, processes for their preparation, pharmaceutical compositions containing them and their use in therapy as anti-hyperchloesterolaemic agents.