TRANS-PT (IV) COMPOUNDS

Trans-Pt(IV) compounds of general formula [PtX2Y2L L )] where X is halogen, Y is halogen, hydroxyl or carboxylate and each L is an amine ligand, providing L and L are not both NH3 are surprisingly active against cancer cells, in contrast to expectations that all trans-Pt compounds are inactive.

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Bibliographische Detailangaben
Hauptverfasser:	BARNARD, CHRISTOPHER F. J
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Trans-Pt(IV) compounds of general formula [PtX2Y2L L )] where X is halogen, Y is halogen, hydroxyl or carboxylate and each L is an amine ligand, providing L and L are not both NH3 are surprisingly active against cancer cells, in contrast to expectations that all trans-Pt compounds are inactive.