ACAT INHIBITORY BENZANILIDES

Benzanilide derivatives of the formula: wherein R is alkyl optionally containing double or triple bonds, and optionally interrupted by one or more hetero atoms; R is hydrogen, methyl, or ethyl; R is halogen, alkyl, -OY, -SOnY, or dimethylamino; R and R are hydrogen, alkyl or (CH2)m-Z, wherein: (i) Z...

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Hauptverfasser:	BRIDGE, ANDREW W
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Benzanilide derivatives of the formula: wherein R is alkyl optionally containing double or triple bonds, and optionally interrupted by one or more hetero atoms; R is hydrogen, methyl, or ethyl; R is halogen, alkyl, -OY, -SOnY, or dimethylamino; R and R are hydrogen, alkyl or (CH2)m-Z, wherein: (i) Z is -OCH3, -SOqCH3, -N(CH3)2 or alkanoylamino, and m is 2, 3 or 4; or (ii) Z is heterocyclyl and m is 0, 1, 2, 3, or 4; X is oxygen, -OCH2-, -SOp-, -SOpCH2- or -NR -; R is hydrogen, methyl, ethyl, or acyl; Y is alkyl; and n, p and q are each 0, 1, or 2; are useful as anti-atherosclerotic agents.