Fibrinolysis-enhancing agents

Fibrinolysis-enhancing agents

Disclosed herein is a fibrinolysis-enhancing agent comprising, as an effective ingredient, an N2-arylsulfonyl-L-arginine amide represented by the general formula (I): (I) wherein R1 is a group of the formula: where R3 is an alkyl group having 3 to 5 carbon atoms or an alkoxyalkyl group having 2 to 4...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KIKUMOTO, RYOJI, TAMAO, YOSHIKUNI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed herein is a fibrinolysis-enhancing agent comprising, as an effective ingredient, an N2-arylsulfonyl-L-arginine amide represented by the general formula (I): (I) wherein R1 is a group of the formula: where R3 is an alkyl group having 3 to 5 carbon atoms or an alkoxyalkyl group having 2 to 4 carbon atoms and R4 is an alkyl group having 1 to 3 carbon atoms; and R2 is a group of the formula: where R5 and R6 are independently hydrogen atom, methyl group or methoxy group provided that they cannot be hydrogen atoms simultaneously, and R7 is an alkyl group having 1 to 3 carbon atoms; or a salt thereof. The agent is used in combination with a plasminogen activator.