DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS

DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS

Novel compounds of the general formula I processes for its preparation, pharmaceutical compositions containing such compounds as the active ingredient and the use of the compounds in medicine, especially for use in inhibiting gastric acid secretion and in the treatment of gastrointestinal inflammato...

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Bibliographische Detailangaben
Hauptverfasser: BRIVING, CARIN B, LINDBERG, PER L, CARLSSON, STIG A. I, MATTSSON, ANNIE H, NORDBERG, MATS P, WALLMARK, BJOERN M. G
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Novel compounds of the general formula I processes for its preparation, pharmaceutical compositions containing such compounds as the active ingredient and the use of the compounds in medicine, especially for use in inhibiting gastric acid secretion and in the treatment of gastrointestinal inflammatory deseases. R represents aryl, cycloalkyl or an adamantyl group. R represents hydrogen, alkyl, alkoxy or halogen. R represents hydrogen, alkyl, phenalkyl or a cykloalkyl-alkyl group. R and R represents hydrogen or alkyl. R represents hydrogen, alkyl, aryl or a hydroxylgroup when n= 1-6 or an amino when n=O. A representents an alkylene, optionally connected to, or interrupted by an optionally substituted heteroatom selected from O,S and NR. n is 0-6.