Platinum containing pullulan derivatives and pharmaceutical compositions comprising the same
A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula occurring at said active sites is partly substituted by a group of the general formula wher...
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Hauptverfasser: | , , , , , , , , , , , , , , , |
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | A pullulan derivative having one or more active sites resulting from introduction of sulfuric acid, phosphoric acid, a sulfonic acid or a carboxylic acid, wherein one hydrogen atom of the group of the formula occurring at said active sites is partly substituted by a group of the general formula wherein L1 and L2 each independently is amine or a unidentate ligand amine or combinedly represent a bidentate ligand amine and Y is an anionic ligand, and/or two hydrogen atoms of the group groups bound to one and the same carbon atom or to two neighboring carbon atoms as occurring at said active sites are, each independently, partly substituted by a group of the general formula wherein L1 and L2 are as defined above, and a pharmacologically acceptable salt thereof. The above compound has anticancer activity and is useful as anticancer agents. The present invention is concerned with said compound, a process for producing the same and a pharmaceutical use thereof. |
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