INDOLE DERIVATIVES

Compounds are disclosed of formula (I) wherein R1 represents H or C1-6 alkyl; R2 represents H, C1-6 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phen(C1-3)alkyl in which the phenyl ring is optionally substituted by halogen, C1-4 alkoxy, hydroxy or C1-3 alkyl; R3 represents H, C1-3 alkyl, -CO2R5, -COR5, -COCO2R5 or -CONHR5 where R5 represents H, C1-4 alkyl, C3-7 cycloalkyl, C2-4 alkenyl, aryl or ar(C1-4)alkyl in which the aryl group is optionally substituted by halogen, C1-4 alkoxy, C1-4 alkyl or hydroxy) (provided that where R3 represents -CO2R5, R5 is other than H); R4 represents H, C1-3 alkyl, C3-6 alkenyl, phenyl or phen(C1-3)alkyl; A-B represents CH-CH2- or C=CH- D represents -CO- or -SO2- n represents 0, 1-5; provided that when D represents -SO2, n is 2, R3 represents H and R4 represents H or C1-3 alkyl, R2 is other than H or C1-6 alkyl; and pharmaceutically acceptable salts and solvates (for example hydrates) thereof. The compounds are indicated as useful for the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders. Processes and intermediates for their preparation and pharmaceutical compositions containing them are also disclosed.