GUANIDINE DERIVATIVES HAVING HYPOTENSIVE ACTIVITY, COMPOSITION CONTAINING THEM AND PROCESS FOR OBTAINING THEM

GUANIDINE DERIVATIVES HAVING HYPOTENSIVE ACTIVITY, COMPOSITION CONTAINING THEM AND PROCESS FOR OBTAINING THEM

Guanidine derivatives of the following formulas (1) and (2): R -NH-(CH2) @NH-@@NH-R (1) wherein: R is hydrogen or optionally substituted cinnamoyl, R is hydrogen, alkyl or alkenyl, with the proviso that R and R cannot be both hydrogen, n is an integer from 1 to 8, or: wherein: R is truxinoyl or a tr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BONNEVAUX, STELLA C, ESPINAL, ROMULO, DE LUCA, CARLO, MONACHE, FRANCO D, CARMIGNANI, MARCO, GIULIANO D, BOTTA, BRUNO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Guanidine derivatives of the following formulas (1) and (2): R -NH-(CH2) @NH-@@NH-R (1) wherein: R is hydrogen or optionally substituted cinnamoyl, R is hydrogen, alkyl or alkenyl, with the proviso that R and R cannot be both hydrogen, n is an integer from 1 to 8, or: wherein: R is truxinoyl or a truxilloyl each optionally substituted, and R and n are as defined above; pharmaceutical compositions containing such compounds and a process for their extraction and purification from plant material, in particular from Verbesina caracasana.