Live vaccine against mumps and process for obtaining thereof

The invention relates to a live vaccine against mumps, which contains live mumps viruses which are capable of multiplication and have been attenuated principally by passages in diploid human tissue cultures. The vaccine is substantially free from proteins and antibiotics. The invention also relates...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GERMANIER, RENE, GLUECK, REINHARD
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a live vaccine against mumps, which contains live mumps viruses which are capable of multiplication and have been attenuated principally by passages in diploid human tissue cultures. The vaccine is substantially free from proteins and antibiotics. The invention also relates to the process for the preparation of a live vaccine against mumps, which comprises obtaining live mumps viruses from the urine of patients with an acute attack of mumps, passaging the viruses in diploid human cells, thereby attenuating the viruses by repeated passages in tissue of this type and, optionally further attenuating the viruses by passaging in embryonic or fertilized chicken eggs, optionally further attenuating the viruses by further passaging in diploid human cells, thereby adapting the viruses to human tissue, isolating, cultivating, and then processing the live mumps viruses.