Process for producing allylic alcohols

Process for producing allylic alcohols

Process for preparing predominantly Z-substituted allylic alcohols of the formula: wherein R1 is a straight or branched C1-C25 alkyl group optionally bearing at least one substituent and/or at least one unsaturated linkage and R2 is a hydrogen atom or a methyl group, which comprises reacting a vinyl...

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Bibliographische Detailangaben
Hauptverfasser: TAMURA, MITSUHISA, HIROSE, KEN-ICHI, SUZUKAMO, GOHU
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Process for preparing predominantly Z-substituted allylic alcohols of the formula: wherein R1 is a straight or branched C1-C25 alkyl group optionally bearing at least one substituent and/or at least one unsaturated linkage and R2 is a hydrogen atom or a methyl group, which comprises reacting a vinyl epoxide of the formula: wherein R2 is as defined above with an organolithium compound of the formula above. More particularly, there is disclosed a process for R1-Li wherein R1 is as defined above; particularly, process for preparing alpha -santalol of the formula: which comprises reacting 3-methyl-3,4-epoxybutene-1 with lithiomethyl-2,3-dimethyltricyclo[2.2.1.02,6]heptane.