Specific ligands for estrogen and progestagen steroid hormone receptors, application and intermediate synthesis products

The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula (I) in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, and Y denotes either a hydroxyl gr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ZEICHER, MARC, QUIVY, JACQUES
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to specific ligands for estrogen or progestagen steroid hormone receptors which have the formula (I) in which X denotes a vinyl group substituted by a radioactive or nonradioactive halogen on the double bond according to a Z isomerism, and Y denotes either a hydroxyl group, in which case the ring to which it is attached is an aromatic ring, or a ketone functional group, in which case it is conjugated with a double bond at C4-C5. An application of the ligands according to the invention is the targeted therapy and/or medical imagery, especially of cancer. However, these ligands can also be employed in the quantitative determination of said hormone receptors. However, the labeled ligands according to the invention are of very particular interest in the case of the targeted radiotherapy of cancer.