Treatment of autoimmune diseases with mycophenolic acid, and derivatives and formulations thereof

Treatment of autoimmune diseases with mycophenolic acid, and derivatives and formulations thereof

The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or -C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft reject...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: EUGUI, ELSIE M, LEE, WILLIAM A, ALLISON, ANTHONY C, GU, CHEE-LIANG L, NELSON, PETER H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The compounds and pharmaceutical compositions of Formula A, wherein Z is hydrogen or -C(O)R, Y is hydrogen or morpholinoethyl, and where R is lower alkyl or aryl, and the pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, particularly for treatment of allograft rejection, especially including cardiac allograft rejection, pancreatic allograft rejection and renal allograft rejection, and for treating autoimmune diabetes. (Formula A)