Arylthiadiazolylsulfonamides and derivatives

There are described compounds of the formula where n is 0, 1 or 2; x and y are independently hydrogen, loweralkyl, loweralkoxy, arylloweralkyl, aryloxy, halogen, -CF3, -NO2, -OH, -OCOR1, where R1 is loweralkyl, arylloweralkyl, aryl or loweralkoxy, R2 is hydrogen, loweralkyl or loweralkylcarbonyl, R3 is hydrogen or loweralkyl, or the group -NR2R3 whole is m is 0, 1 or 2, and R4 is hydrogen, loweralkyl or aryl; and Z is (R5, R6), where R5 and R6 are each independently hydrogen or loweralkyl, R7 loweralkyl, R8 is hydrogen, loweralkyl or aryl, R9 and R10 are each independently loweralkyl or the group -NR9R10 as a whole is +TR R12 being hydrogen, loweralkyl or aryl, and R11 is hydrogen, loweralkyl or aryl; which are useful for the treatment of glaucoma.