Process for the preparation of pharmaceutical compositions

Process for the preparation of pharmaceutical compositions

PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R st...

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Hauptverfasser: JELINEK, ISTVAN, SANTA NEE SINGOLA, ILONA, SIMANDI, LASZLO, SZALAY, ERZSEBET, NAD, ZSUZSANNA, LUGOSI, GYOERGY, GYORY, PETER, MARTA, BESENYEI, GABOR, NAGY, LAJOS, KALLAY, TAMAS U, SIMONIDESZ, VILMOS
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Zusammenfassung:PCT No. PCT/HU88/00063 Sec. 371 Date May 5, 1989 Sec. 102(e) Date May 5, 1989 PCT Filed Sep. 16, 1988 PCT Pub. No. WO89/02429 PCT Pub. Date Mar. 23, 1989.The invention relates to a process for the preparation of tetracycline derivatives of the formula I. and acid addition salts thereof -wherein R stands for -CH3 or =CH2-by dehalogenating and hydrogenating chloromethacycline or acid addition salt thereof of the formula II. or by hydrating methacycline or acid addition salts thereof of the formula III. by treatment with hydrogen gas in the presence of a noble metal alloy catalyst on carrier and organic solvent which comprises performing, hydrogenating under pressure of 0.1-1.0 MPa with an alloy catalyst consisting of the alloy palladium or platinum and selenium and/or tellurium used at a ratio of 1:0.01-0.5 related to the amount of the starting tetracycline and carrying out, if desired dehalogenation and hydrogenation in one step.