Benzimidazolesulfonamides and imidazopyridinesulfonamides, and their application as drugs

2-Benzimidazolsulphonamide and 2-imidazopyridinesulphonamide derivatives corresponding to the general formula I and their pharmaceutically acceptable salts, especially formula in which: Z to Z denote a nitrogen atom or a substituted or unsubstituted carbon atom, R and R denote a hydrogen atom or an...

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Hauptverfasser: PINOL, AUGUSTO C, COROMINAS, JUAN P, CONSTANSA, JORDI F
Format: Patent
Sprache:eng
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Zusammenfassung:2-Benzimidazolsulphonamide and 2-imidazopyridinesulphonamide derivatives corresponding to the general formula I and their pharmaceutically acceptable salts, especially formula in which: Z to Z denote a nitrogen atom or a substituted or unsubstituted carbon atom, R and R denote a hydrogen atom or an alkyl, alkylaryl, alkylcarbonylalkyl, alkylcarbonylaryl, alkylcarbonylheteroaryl, cycloalkyl, carboxyalkyl, acyl or nitro radical, or R to R can together form a bond denoted by a group X; R denotes a hydrogen atom or an alkyl, aryl, heteroaryl, alkylaryl, hydroxyalkyl, alkylheteroaryl, mono-, di- or tricycloalkyl, alkylamino, N-alkylalkylamino, alkylcarboxyalkyl, acyl, alkylthio (or sulphinyl, or sulphonyl)alkyl, alkylthio (or sulphinyl or sulphonyl)aryl, alkylthio (or sulphinyl or sulphonyl)heteroaryl, alkylthio (or sulphinyl or sulphonyl)alkylaryl, alkylthio (or sulphinyl or sulphonyl)alkylheteroaryl, haloalkyl, cyanoalkyl, N- alkylarylalkylamino, N-alkyl-N-alkylarylalkylamino, N,N- dialkylalkylamino, alkylpiperazinyl, alkylpiperidinyl or alkylmorpholinyl radical; X denotes -(CHR )n-(CHR )m- or -CR =CR -; R and R denote a hydrogen atom or a lower alkyl, aryl or heteroaryl radical, R denotes a hydrogen atom, a -CH2OH radical, a -CH2Cl radical or a (-CH2-)10 methylene radical; R may form a bond with R in the case where R denotes a methylene (-CH2-) radical and itself (R ) denotes a bond; R denotes a hydrogen atom, an alkyl radical or a hydroxyalkyl radical.