Method for continuous centrifugal bioprocessing

Bioprocessing apparatus and method using centrifugal acceleration of cells to maintain a culture within a reaction zone. The reactor has an inflow at a relatively distance inlet and an outflow at an inwardly spaced point toward the rotational axis. The reaction chamber has an inwardly diverging zone...

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Bibliographische Detailangaben
Hauptverfasser:	ELLIOTT, MICHAEL L, VAN WIE, BERNARD J, BROUNS, THOMAS M
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL ORCHEMICAL PROCESSES CENTRIFUGES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TRANSPORTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Bioprocessing apparatus and method using centrifugal acceleration of cells to maintain a culture within a reaction zone. The reactor has an inflow at a relatively distance inlet and an outflow at an inwardly spaced point toward the rotational axis. The reaction chamber has an inwardly diverging zone with a velocity gradient which captures cells of varying sizes. A recycle system is preferably used to recycle medium containing nutrients for the culture microbes. Byproducts of the cells are removed by the circulated medium and can be extracted using a desired extraction process.