Use of tetrazole derivatives

The invention provides a method for the treatment of a human or animal patient suffering from, or subject to, an arthritic or related autoimmune disorder, a connective tissue disorder or transplant rejection, using a compound which is a tetrazole derivative of the formula: wherein R represents halog...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WALKER, JOYCE L
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention provides a method for the treatment of a human or animal patient suffering from, or subject to, an arthritic or related autoimmune disorder, a connective tissue disorder or transplant rejection, using a compound which is a tetrazole derivative of the formula: wherein R represents halogen, alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphamoyl, dialkylsulphamoyl, dialkylamino, dialkylcarbamoyl, alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl, alkanoylamino, cycloalkylcarbonyl, hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl, aroyl, or a group of the formula -CR =NOR wherein R represents hydrogen, alkyl, aryl, aralkyl, trifluoromethyl or cycloalkyl, and R represents hydrogen, alkyl, optionally substituted by phenyl, or represents optionally substituted aryl and m represents zero, 1, 2 or 3, or a pharmaceutically acceptable salt thereof.