Process for the preparation of 3-cyano-4-aryl-pyrroles

Process for the preparation of 3-cyano-4-aryl-pyrroles

A process for the preparation of a 3-cyano-4-aryl-pyrrole of the formula (I) in which Ar is optionally substituted heteroaryl or aryl, which comprises (a) reacting an alpha -cyanoacrylic acid derivative of the formula (II) in which R1 is amino or alkoxy, with an isocyanoacetic acid ester of the form...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WOLLWEBER, DETLEF
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of a 3-cyano-4-aryl-pyrrole of the formula (I) in which Ar is optionally substituted heteroaryl or aryl, which comprises (a) reacting an alpha -cyanoacrylic acid derivative of the formula (II) in which R1 is amino or alkoxy, with an isocyanoacetic acid ester of the formula (III) in which R2 is alkyl, in the presence of a base thereby to produce a DELTA 2-pyrroline-2-carboxylic acid derivative of the formula (IVa) in which X represents hydrogen or an equivalent of an inorganic or organic cation, and (b) oxidatively decarboxylating the DELTA 2-pyrroline-2-carboxylic acid. The end products are known fungicides and the intermediates IVa are new and themselves fungicidally active.