Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids

The present invention relates to compounds of the formula wherein A is a bivalent radical of the formula -CmH2m- wherein m is an integer having a value from 0 to 20, inclusive; A is a bivalent radical of the formula -CpH2p- wherein p is an integer having a value from 2 to 6, inclusive; X is a bivale...

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Hauptverfasser: TEGELER, JOHN J, HRIB, NICHOLAS J, SHOGER, KIRK D
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to compounds of the formula wherein A is a bivalent radical of the formula -CmH2m- wherein m is an integer having a value from 0 to 20, inclusive; A is a bivalent radical of the formula -CpH2p- wherein p is an integer having a value from 2 to 6, inclusive; X is a bivalent radical of the formula -O- or -N(R)- wherein R is selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, inclusive, and phenyl radical of the formula: wherein a is an integer having a value from 0 to 3, inclusive, and Z is selected from the group consisting of alkyl radicals having 1 to 6 carbon atoms, inclusive, alkoxy radicals having 1 to 6 carbon atoms, inclusive, halogen, hydroxy, and trifluromethyl radicals, wherein for each value of a, Z may be the same or different; Y is wherein R is alkyl having 1 to 6 carbon atoms, inclusive and R and R are independently alkyl radicals having 1 to 6 carbon atoms, inclusive, or, taken together with R and the nitrogen atom to which they are attached form a group of the formula wherein r is 0 or 1, W is oxygen, CH2, sulfur or N(R ) wherein R is an alkyl radical having 1 to 6 carbon atoms, inclusive or aryl; and n is an integer having a value of 3 or 4 and the geometrical isomers, or optical antipodes thereof, and a process for their preparation. The compounds have anti-inflammatory activity and can, therefore, be used as medicaments.