Bis-dioxopiperazine derivatives and pharmaceutical compositions containing the same

Bis-dioxopiperazine derivatives and pharmaceutical compositions containing the same

PCT No. PCT/JP86/00324 Sec. 371 Date Feb. 24, 1987 Sec. 102(e) Date Feb. 24, 1987 PCT Filed Jun. 25, 1986 PCT Pub. No. WO87/00170 PCT Pub. Date Jan. 15, 1987.Novel bis-dioxopiperazine derivatives represented by the following formula (I) and having a broader antitumor spectrum as well as pharmaceutic...

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Hauptverfasser: CAI, JUNAO, TAKASE, MUNEAKI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PCT No. PCT/JP86/00324 Sec. 371 Date Feb. 24, 1987 Sec. 102(e) Date Feb. 24, 1987 PCT Filed Jun. 25, 1986 PCT Pub. No. WO87/00170 PCT Pub. Date Jan. 15, 1987.Novel bis-dioxopiperazine derivatives represented by the following formula (I) and having a broader antitumor spectrum as well as pharmaceutical compositions containing the compounds as antitumor active components: (I) wherein R1 represents a lower alkyl group; A represents an oxygen atom, a sulfur atom or a group of wherein R2 represents a hydrogen atom, a lower alkyl group or phenyl; R3 represents a lower alkyl group, phenyl or benzyl; and X and Y, which are respectively independent and are the same or different, represent a hydrogen atom or a lower alkyl group.