N-acyl derivatives of thienamycin

N-acyl derivatives of thienamycin

Disclosed are N-acyl derivatives of the antibiotic thienamycin having the following structural formula: wherein R1 and R2 are independently selected from the group consisting of hydrogen and acyl. Such derivatives and their pharmaceutically acceptable salts, are useful as antibiotics. Also disclosed...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LEANZA, WILLIAM J, BARASH, LOUIS, CHRISTENSEN, BURTON G, HANNAH, JOHN, SHIH, DAVID H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are N-acyl derivatives of the antibiotic thienamycin having the following structural formula: wherein R1 and R2 are independently selected from the group consisting of hydrogen and acyl. Such derivatives and their pharmaceutically acceptable salts, are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.