N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders

Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	WATTS, ERIC A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	WATTS ERIC A
description	Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US4816453A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US4816453A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US4816453A3</originalsourceid><addsrcrecordid>eNqFjLEKwkAQRNNYiPoN7g-kkESxFVGsbNQ6nHeTZOG8C7drQL_eE-ythje8mWlhz2UPRYr2ZT1bckg8GuURQrGlO8LbPNhlMsGR9uBETwFxIE3IYuioM6Ipb78GB4Xk1nhyLDHlP5kXk9Z4weKXs2J5PFz3pxJDbCCDsQjQ5napt6tNva521X_jA9sBPkM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders</title><source>esp@cenet</source><creator>WATTS; ERIC A</creator><creatorcontrib>WATTS; ERIC A</creatorcontrib><description>Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890328&DB=EPODOC&CC=US&NR=4816453A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890328&DB=EPODOC&CC=US&NR=4816453A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WATTS; ERIC A</creatorcontrib><title>N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders</title><description>Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjLEKwkAQRNNYiPoN7g-kkESxFVGsbNQ6nHeTZOG8C7drQL_eE-ythje8mWlhz2UPRYr2ZT1bckg8GuURQrGlO8LbPNhlMsGR9uBETwFxIE3IYuioM6Ipb78GB4Xk1nhyLDHlP5kXk9Z4weKXs2J5PFz3pxJDbCCDsQjQ5napt6tNva521X_jA9sBPkM</recordid><startdate>19890328</startdate><enddate>19890328</enddate><creator>WATTS; ERIC A</creator><scope>EVB</scope></search><sort><creationdate>19890328</creationdate><title>N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders</title><author>WATTS; ERIC A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US4816453A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WATTS; ERIC A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WATTS; ERIC A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders</title><date>1989-03-28</date><risdate>1989</risdate><abstract>Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_US4816453A
source	esp@cenet
subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A00%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WATTS;%20ERIC%20A&rft.date=1989-03-28&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS4816453A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true