N-heterocyclic derivatives of benzamides and their use in treating gastric and intestinal disorders

Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6...

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Bibliographische Detailangaben
Hauptverfasser:	WATTS, ERIC A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula (i) and pharmaceutically acceptable salts thereof: (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals.