4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]-oxazepin-5(6H)-ones

The present application relates to 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]oxazepin-5(6H)-ones of the formula I wherein R is hydrogen, loweralkyl, arylloweralkyl, aryloxyloweralkyl, cycloalkylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, diloweralkylaminoloweralkyl, and loweralkoxycarbonyll...

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Bibliographische Detailangaben
Hauptverfasser:	TEGELER, JOHN J, SHOGER, KIRK D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]oxazepin-5(6H)-ones of the formula I wherein R is hydrogen, loweralkyl, arylloweralkyl, aryloxyloweralkyl, cycloalkylloweralkyl, aminoloweralkyl, loweralkylaminoloweralkyl, diloweralkylaminoloweralkyl, and loweralkoxycarbonylloweralkyl; R is hydrogen or loweralkyl; Y is independently loweralkyl, loweralkoxy, halogen, trifluoromethyl or nitro; and n is an integer having a value from 0 to 2, inclusive; the geometrical isomers; optical antipodes, and pharmaceutically acceptable acid addition salts thereof. The compounds of the formula I have antihypertensive activity and can, therefore, be used as medicaments.