Complexes of technetium-99m with propylene amine oximes

A family of propylene amine oxime ligands has the formula 2 2. wherein preferably R1 is Cl-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly fo...

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Bibliographische Detailangaben
Hauptverfasser:	PIPER, IAN M, NOWOTNIK, DAVID P, CANNING, LEWIS R, NEIRINCKX, RUDI D
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A family of propylene amine oxime ligands has the formula 2 2. wherein preferably R1 is Cl-C4 alkyl or phenyl and each of R, R2, R3 and R4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R1=R2=CH3, R3=R4=H) show good retention in the brain.