Suppository dosage form

Suppositories containing as the active substance a therapeutically effective amount of ceftriaxone, a pharmaceutically compatible salt thereof or a hydrate of one of these compounds, a stabilizer consisting of a mono-, di- or triglyceride of a C12-C18-fatty acid or of a mixture of such glycerides, a potentiator consisting of an aliphatic C2-C18-fatty acid, a mono-, di- or triglyceride of a C2-C12-fatty acid, a partial ester or complete ester of propylene glycol, polyethylene glycol or a carbohydrate with a C2-C12-fatty acid, a pharmaceutically compatible ester or ether thereof or of a mixutre of the said potentiators and, if desired, customary therapeutically inert adjuvants for suppositories, and their manufacture are described. These have valuable antimicrobial properties.