6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof

6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for the preparation thereof

6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-c...

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Bibliographische Detailangaben
Hauptverfasser: REICHLOVA, RUZENA, CERNY, ANTONIN, BEITOVA, MARTA, MIKO, MILAN, KREPELKA, JIRI, POKORNA, STANISLAVA, MELKA, KEJHOVA, IRENA, GRIMOVA, JAROSLAVA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.