Antianginal film and method of treating ischemic heart disease

The antianginal film is a plate, 0.1 to 1.5 thick, consisting of a biologically soluble and resolvable carrier, which is a hompolymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to...

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Hauptverfasser: DAVYDOV, ANATOLY B, UTYAMYSHEV, RUSTAM I, KHROMOV, GENNADY L, BABAIAN, EDUARD A, METELITSA, VLADIMIR I, SAVVATEEV, KONSTANTIN L, NOVIKOVA, ELIZAVETA B, GERASIMOVA, GALINA A, VIKHERT, ANATOLY M, PIOTROVSKY, VLADIMIR K
Format: Patent
Sprache:eng
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Zusammenfassung:The antianginal film is a plate, 0.1 to 1.5 thick, consisting of a biologically soluble and resolvable carrier, which is a hompolymer of acrylamide or vinylpyrrolidone, or a copolymer thereof with acrylate, containing from 99 to 70 percent by weight of acrylamide with vinylpyrrolidone and from 1 to 30 percent by weight of acrylate having a molecular mass from 50,000 to 1,000,000, and the active principle having antianginal action, the components being taken in the following proportions, in percent by weight: active substance having antianginal action 3.0-30.0 biologically soluble and resolvable carrier 70.0-97.0 The method of treating ischemic heart disease with the proposed antianginal film by individual doses, consists in that a biologically soluble and resolvable film without any active substance is first applied to a selected site of the mouth mucosa and the time during which this film is fully resolved is determined, this time being characteristic of the period during which the active substance is delivered into the patient's body. Next a medicinal film containing the active substance in the quantity which should be delivered into the patient's body during the time of the film resolution is selected. Finally the film containing the required quantity of the antianginal preparation is applied once or several times, to the selected site of the mouth mucosa to ensure continuous and optimal therapeutic effect during the entire period of the full resolution of the proposed film.