Process for the preparation of benzimidazole-thiol

Process for the preparation of benzimidazole-thiol

A new process is disclosed for preparing a compound of the formula (I) wherein R is C1 to C5 alkyl; which comprises reducing a compound of the formula (II) or salt thereof wherein A is -SO2X, -SOH, -SOA1, or -SA1 group, X is chlorine or hydrogen; and A1 is a group of the Formula with the aid of alum...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BAKONYI, MARIA, MONTAI, TIBOR, LUGOSI, GYOERGY, HIMA NEE TOTH, KALLAI, TAMAS, SZILADI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A new process is disclosed for preparing a compound of the formula (I) wherein R is C1 to C5 alkyl; which comprises reducing a compound of the formula (II) or salt thereof wherein A is -SO2X, -SOH, -SOA1, or -SA1 group, X is chlorine or hydrogen; and A1 is a group of the Formula with the aid of aluminum activated with a catalytic amount of a metal and/or metal salt in a mixture of water, a mineral acid, and an aliphatic carboxylic acid having 1 to 3 carbon atoms at a temperature of 0 DEG to 100 DEG C., thereafter, optionally, the product is recovered from an acid medium at a pH range of 2 to 3 in crystalline form.