Pyrazole derivatives with an ergoline skeleton, their acid addition salts, and a process for the preparation thereof

The invention relates to novel pyrazole derivatives with an ergoline skeleton of the general formula I, I wherein x . . . y stands for a R is a hydrogen atom or methyl group, R1 stands for a hydrogen atom, C1-4 alkyl, carbethoxy or pyridyl-group, R2 stands for a hydrogen atom, C1-4 alkyl, allyl, C2-4 oxoalkyl-, C2-4 hydroxyalkyl or C2-4 hydroxyiminoalkyl group, R3 stands for a hydrogen atom, C1-4 alkyl, hydroxy or pyridyl group, furthermore R2 and R3 may stand together for a group of general formula (II), II wherein Z stands for a methylene, carbonyl, hydroxymethylene or hydroxyiminomethylene group, R4 stands for a hydrogen atom or one or two C1-4 alkyl group(s), and n is 1 or 2, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to a process for the preparation of these compounds. The novel compounds are potent PGF2 alpha receptor antagonists.