Derivatives of (E)-3-(4-oxo-4H-quinazolin-3-yl)-2-propenamide

Compounds of the formula I wherein R1 is hydrogen, lower alkyl, lower cycloalkyl, lower alkoxy, hydroxy, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, di-(C1-C7) alkyl-N(CH2)nO- or 2-hydroxyethoxy; n is 2 to 7; R2 is hydrogen, lower alkyl or lower alkoxy; R3 is hydrogen or methyl; R4 is hydrogen or lower alkyl; R5 is hydrogen or lower alkyl provided however if R2 is other than hydrogen R5 is hydrogen; m is 1 to 7; Y is -O- or -S-; w is zero or one; and A is an unsubstituted or substituted aromatic 5- or 6-membered heterocyclic radical; or pharmaceutically acceptable addition salts thereof are described. The compounds of formula I are useful for treating allergic conditions and vascular disorders.