Modified tripeptides

Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from -CH2NH-, -CH2O-, -CH2S-, -CH2SO-, -CH2SO2-, -CH2CH2- and -CH=CH- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of...

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Hauptverfasser: REPINE, JOSEPH T, LUNNEY, ELIZABETH A, NICOLAIDES, ERNEST D, ROARK, W. HOWARD, TINNEY, FRANCIS J, DEJOHN, DANA E, KALTENBRONN, JAMES S
Format: Patent
Sprache:eng
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Zusammenfassung:Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from -CH2NH-, -CH2O-, -CH2S-, -CH2SO-, -CH2SO2-, -CH2CH2- and -CH=CH- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of cognitive disorders, depression, morphine dependency and parkinsonism by adjunctive therapy.