Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites
Radiolabeled angiotensin converting enzyme inhibitors having the general formula: wherein X is a radiolabeling substituent, preferably a radiolabeling halogen substituent such as 123I, 125I, 131I, 75Br or 77Br, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy, or amino, R...
Gespeichert in:
Hauptverfasser: | , , , , , |
---|---|
Format: | Patent |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Radiolabeled angiotensin converting enzyme inhibitors having the general formula: wherein X is a radiolabeling substituent, preferably a radiolabeling halogen substituent such as 123I, 125I, 131I, 75Br or 77Br, Y is hydroxy, alkoxy containing from 1 to 6 carbon atoms, phenoxy, benzyloxy, or amino, R1 is hydrogen or methyl, R2 is hydrogen, an ester moiety hydrolyzable under mammalian in vivo conditions, such as alkyl of 1 or 2 carbon atoms, phenyl or benzyl, or an ionically bonded anion of a physiologically acceptable non-toxic salt, and m is an integer of from 1 to 6, are useful as in vivo radioimaging compounds for mammalian sites. |
---|