Contraceptive vaginal tablets

PCT No. PCT/HU83/00052 Sec. 371 Date Jun. 7, 1984 Sec. 102(e) Date Jun. 7, 1984 PCT Filed Oct. 7, 1983 PCT Pub. No. WO84/01502 PCT Pub. Date Apr. 26, 1984.The invention relates to contraceptive vaginal tablets as well as to a process for preparing them. The tablets of the invention have the followin...

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Hauptverfasser: KOESZEGI, BELA, SZEBENI, RUDOLF, KOVACS, ANDRAS
Format: Patent
Sprache:eng
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Zusammenfassung:PCT No. PCT/HU83/00052 Sec. 371 Date Jun. 7, 1984 Sec. 102(e) Date Jun. 7, 1984 PCT Filed Oct. 7, 1983 PCT Pub. No. WO84/01502 PCT Pub. Date Apr. 26, 1984.The invention relates to contraceptive vaginal tablets as well as to a process for preparing them. The tablets of the invention have the following composition: 0.2 to 3 parts by weight of boric acid, 10 to 20 parts by weight of tartaric acid, 1 to 2 parts by weight of vitamin K3-sodium bisulfite adduct, 0.8 to 1.2 parts by weight of polyvinyl pyrrolidone, 2 to 5 parts by weight of magnesium stearate, 8 to 12 parts by weight of carboxymethyl cellulose, 8 to 12 parts by weight of lactose and 50 to 65 parts by weight of microcrystalline cellulose. The vaginal tablets contain preferably 5 to 10 mg of vitamin K3-sodium bisulfite adduct and have a total weight of 500 mg. The tablets of the invention are prepared preferably in such way that the boric acid, the tartaric acid and the vitamin K3-sodium bisulfite adduct, as well as the polyvinyl pyrrolidone, the magnesium stearate, the carboxymethyl cellulose, the lactose and the microcrystalline cellulose are homogenized separately to powder mixtures thereafter the powder mixtures are mixed and pressed to tablets. The tablets should be wetted and put into the back-vaginal fornix 10 minutes before the coitus.