Method and intermediates for producing alpha -L-aspartyl-L-phenylalanine

This invention encompasses a method and intermediates for preparing a commercial sweetening agent, alpha -L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydrid...

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Bibliographische Detailangaben
Hauptverfasser:	DRYDEN, JR, HUGH L, HILL, JOHN B
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PEPTIDES TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS
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Beschreibung
Zusammenfassung:	This invention encompasses a method and intermediates for preparing a commercial sweetening agent, alpha -L-aspartyl-L-phenylalanine methyl ester. The process involves reacting L-aspartic acid with diketene to form N-acetoacetyl-L-aspartic acid which is converted to N-acetoacetyl-L-aspartic anhydride by reaction with acetic anhydride. N-acetoacetyl-L-aspartic anhydride is reacted with L-phenylalanine methyl ester to provide N-acetoacetyl- alpha -L-aspartyl-L-phenylalanine methyl ester which is converted to alpha -L-aspartyl-L-phenylalanine methyl ester by reaction with hydroxylamine hydrochloride.