Integrated hybrid image remasking in a subtraction angiography method

In a subtraction angiography hybrid difference images are generated and reviewed visually. Hybrid images that exhibit no x-ray contrast medium and are free of artifacts are identified and selected for forming an integrated mask image. Hybrid images that exhibit contrast medium and are free of artifacts are identified and selected for forming an integrated contrast medium image. The selected images that exhibit no contrast medium are integrated and those that exhibit contrast medium are integrated separately. The result of one integration is subtracted from the other to yield a single final image that exhibits substantially only the contrast medium in a blood vessel. In an alternate method temporal difference images are reviewed and a similar selection of some that exhibit no contrast medium and some that exhibit contrast medium is made. These images are separately integrated and subtracted to yield a single final image that exhibits substantially only contrast medium in the blood vessel.