Synthesis of d1-(methyl)-16,16-(dimethyl-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans,trans-prostadienoates

Synthesis of d1-(methyl)-16,16-(dimethyl-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans,trans-prostadienoates

A conjugate addition reaction and novel intermediate compounds are disclosed, whereby the reaction of with a lithio-cuprate reagent produces compounds of the class: A new process is disclosed for preparing 1-(methyl)-16,16-(dimethyl)-11-alpha-15-alpha-dihydroxy-9-oxo-2,13,tra ns,trans-prostadienoate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: FLOYD, JR., MIDDLETON B
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A conjugate addition reaction and novel intermediate compounds are disclosed, whereby the reaction of with a lithio-cuprate reagent produces compounds of the class: A new process is disclosed for preparing 1-(methyl)-16,16-(dimethyl)-11-alpha-15-alpha-dihydroxy-9-oxo-2,13,tra ns,trans-prostadienoate, and congeners thereof, including racemic mixtures.