Pharmaceutically active aza-bicyclo benzamide derivatives

Compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) wherein: n, p and q independently are 0 to 2; R5 is hydrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group -(CH2)sR7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group -(CH2)tR8 where t is 1 or 2 and R8 is C2-5 alk...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: WATTS, ERIC A
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) wherein: n, p and q independently are 0 to 2; R5 is hydrogen or C1-6 alkyl; R6 is C1-7 alkyl or a group -(CH2)sR7 where s is 0 to 2 and R7 is a C3-8 cycloalkyl group, or a group -(CH2)tR8 where t is 1 or 2 and R8 is C2-5 alkenyl or a phenyl group optionally substituted by one or two substituents selected from C1-6 alkyl, C1-4 alkoxy, trifluoromethyl and halogen, or a thienyl group; R12 is C1-6 alkylsulphonyl; and either R1 is C1-6 alkoxy or C1-6 alkylthio; and one of R2 and R11 is hydrogen and the other is C1-6 alkoxy, C1-6 alkyl or hydroxy; or R1 and R2 together are C1-3 alkylenedioxy; and R11 is hydrogen, halogen, CF3, C1-6 alkoxy, hydroxy, nitro, C1-7 acyl, amino, C1-7 acylamino, aminocarbonyl optionally substituted by one or two C1-6 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-4 alkyl, phenyl or phenyl C1-4 alkyl groups any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkoxy or nitro groups or N-disubstituted by C4-6 polymethylene, having useful pharmacological activity, e.g. in the treatment of impaired gastric motility, a process for their preparation and their use.