2-(o-Carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof, and application as antiphlogistics

2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 has the structural formula Derivatives thereof have the structural formulas where A+ are alkali metals, monoethanolamine, diethylamine. where R is OH, alkyloxyl C 1-4, NHR1, where R1 is H, alkyl C 1-4, phenyl, aralkyl. A are salts of inorgani...

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Hauptverfasser: TRINUS, FEDOR P, FADEICHEVA, ALEXANDRA G, KOZHUSHKO, GALINA I, MEDVEDOVSKY, ADOLF A, PANTELEIMONOV, ALEXANDR G, RYABUKHA, TATYANA K, KIRICHEK, LARISA M, USENKO, JURY D, KARP, VALENTINA K, DOBROVOLSKY, JURY N, PORTNYAGINA, VERA A, MOKHORT, NIKOLAI A, SIDELNIKOV, VIKTOR M, SOLSKY, YAKOV P, BARKOVA, IRINA S, GETMAN, GALINA A, DANILEVSKY, NIKOLAI F, KLJUSHIN, VIKTOR V
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Sprache:eng
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Zusammenfassung:2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 has the structural formula Derivatives thereof have the structural formulas where A+ are alkali metals, monoethanolamine, diethylamine. where R is OH, alkyloxyl C 1-4, NHR1, where R1 is H, alkyl C 1-4, phenyl, aralkyl. A are salts of inorganic acids where R is alkyloxyl C 1-4, NHR', where R' is alkyl C 1-4. A method of producing 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof consists in that 2,4-dichloropyrimidine is brought into interaction with anthranilic acid, or a sodium salt of anthranilic acid, or substituted esters, or amides of anthranilic acid in an aqueous medium, or in an organic solvent at a temperature of 90 DEG to 120 DEG C., is kept at this temperature for 1 to 4 hours, and an end product is separated using a conventional method. A chemotherapeutic antiphlogistic, containing as an acting source 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 or derivatives thereof, and a pharmaceutical basic material.