Phenyl-lower-alkyl piperidines and pyrrolidines

N-{2, 3- and 4-[R1-(phenyl)-C(=X)]-phenyl-loweralkyl} amines, useful as anti-inflammatory agents, are prepared either by reduction of 2-, 3- or 4-[R1-(phenyl)CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-loweralkylamine; by reaction of a...

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Bibliographische Detailangaben
Hauptverfasser: ZENITZ, BERNARD L
Format: Patent
Sprache:eng
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Zusammenfassung:N-{2, 3- and 4-[R1-(phenyl)-C(=X)]-phenyl-loweralkyl} amines, useful as anti-inflammatory agents, are prepared either by reduction of 2-, 3- or 4-[R1-(phenyl)CO]-phenyl-lower-alkanoylamines, which are also useful as anti-inflammatory agents; by benzoylating a phenyl-loweralkylamine; by reaction of a 2-, 3- or 4-lithiophenyl-loweralkylamine with a R1-(phenyl)-carboxaldehyde, a R1-(phenyl)-lower-alkyl ketone or a R1-(phenyl)-carbonitrile; by reaction of a 2-, 3- or 4-[R1-(phenyl)-CO]-phenyl-lower-alkyl tosylate with an appropriate amine; or by transformations involving manipulations of a carbonyl or carbinol group.