Intermediates in the preparation of ranitidine

Intermediates in the preparation of ranitidine

The invention relates to a process for the preparation of ranitidine of formula (I) (I) which comprises reacting a thiol of formula (II) (II) with an alkylating agent of formula (III) (III) where L is a leaving group, preferably halogen. The invention also relates to novel intermediates, the thiol o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CLITHEROW, JOHN W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of ranitidine of formula (I) (I) which comprises reacting a thiol of formula (II) (II) with an alkylating agent of formula (III) (III) where L is a leaving group, preferably halogen. The invention also relates to novel intermediates, the thiol of formula (II) (II) in the form of a stable acid addition salt, and the isothiourea of formula (IV) (IV) and stable acid additions salts thereof.