Process for the preparation of a furan derivative

Process for the preparation of a furan derivative

Ranitidine is prepared by reacting cystamine of formula (II) (II) either with a nitroethenamine of formula (III) (III) where L is a leaving group such as alkylthio, e.g. methylthio, or with a compound of formula (IV) (IV) where L is a leaving group as defined above, followed by reaction with methyla...

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Bibliographische Detailangaben
Hauptverfasser: CLITHEROW, JOHN W
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Ranitidine is prepared by reacting cystamine of formula (II) (II) either with a nitroethenamine of formula (III) (III) where L is a leaving group such as alkylthio, e.g. methylthio, or with a compound of formula (IV) (IV) where L is a leaving group as defined above, followed by reaction with methylamine, to give a disulphide of formula (V) (V) which is then reacted with 5-[(dimethylamino)methyl]-2-furanmethanol under acid conditions.