2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives

2-Thioxobenz[cd]indole-1(2H)-acetic acid derivatives

Herein are disclosed compounds of the formula in which R1 is hydrogen, lower alkyl or -(CH2)m-NR4R5 wherein m is an integer from 2 to 6 and R4 and R5 each is hydrogen or lower alkyl; R2 is hydrogen, bromo or chloro; and R3 is hydrogen or halo; with the requirement that when R2 is bromo or chloro, th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SESTANJ, KAZIMIR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Herein are disclosed compounds of the formula in which R1 is hydrogen, lower alkyl or -(CH2)m-NR4R5 wherein m is an integer from 2 to 6 and R4 and R5 each is hydrogen or lower alkyl; R2 is hydrogen, bromo or chloro; and R3 is hydrogen or halo; with the requirement that when R2 is bromo or chloro, then R3 is bromo or chloro or a therapeutically acceptable salt thereof. The compounds inhibit lens aldose reductase in a diabetic mammal.