Phenol ethers

Phenol ethers

The invention provides phenol ethers of the formula: wherein R is branched C3-4 alkyl, C3-4 cycloalkyl, branched cyano(C3-4 alkyl), phenyl(C2-3 alkyl), halophenyl(C2-3 alkyl), (C1-4 alkoxy)phenyl(C2-4 alkyl), or (C1-4 acyl)amino(C1-4 alkyl), alk is C1-4 alkyl substituted by a 3 to 6 membered cycloal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GIUDICELLI, DON PIERRE R. L, MANOURY, PHILIPPE M. J, CAVERO, ICILIO A. G, NAJER, HENRY
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides phenol ethers of the formula: wherein R is branched C3-4 alkyl, C3-4 cycloalkyl, branched cyano(C3-4 alkyl), phenyl(C2-3 alkyl), halophenyl(C2-3 alkyl), (C1-4 alkoxy)phenyl(C2-4 alkyl), or (C1-4 acyl)amino(C1-4 alkyl), alk is C1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group, X is -O-, -S- or -SO2-; and R1 is -C1-4 alkyl- or -C1-4 alkoxy-, in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as beta -adrenergic blocking agents. Intermediates are also provided.