3,5-Dihydroxypentanoic ester derivatives having antihyperlipaemic activity

3,5-Dihydroxypentanoic ester derivatives having antihyperlipaemic activity

3,5-Dihydroxypentanoic ester derivatives of formula (I): (I) wherein: A represents an alkylene group which is optionally substituted by one or more alkyl groups, or an alkenylene group; Z represents a substituted or unsubstituted aryl or aryloxy group; and R represents a C1-C4 alkyl group) may be pr...

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Bibliographische Detailangaben
Hauptverfasser: ENDO, AKIRA, OKA, HIDEHIKO, TERAHARA
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:3,5-Dihydroxypentanoic ester derivatives of formula (I): (I) wherein: A represents an alkylene group which is optionally substituted by one or more alkyl groups, or an alkenylene group; Z represents a substituted or unsubstituted aryl or aryloxy group; and R represents a C1-C4 alkyl group) may be prepared by reacting a dianion of an acetoacetic ester with an aldehyde of formula Z-A-CHO (wherein A and Z are as defined above) and then reducing the resulting compound. These 3,5-dihydroxypentanoic ester derivatives have antihyperlipaemic activity and are thus valuable pharmaceuticals.